And non sedating
Astemizole and terfenadine had shown cardiotoxic effects. Chronic urticaira has impact on physical as well as mental health of patient. All are single arm and non-randomzied studies. Urticaria patients suffer from intense pruritus associated with raised wheals, with or without edema of the deeper cutis. Limitations of older first generation antihistamines Older first generation antihistamines may lead to anticholinergic effects and have sedative actions.
This article reviewed Indian data on up-dosing of antihistamines in chronic urticaria. Nonsedating antihistamines, also called new, or second-generation antihistamines, are just as effective against nasal allergy symptoms as older medications. Three studies with different antihistamines were found in the literature.
Urticaria is usually acute and self-limited, but can be chronic in some cases. For many people, sedating antihistamines, also called old, classic, or first-generation antihistamines, cause sleepiness, grogginess, and slow reaction time.
Cetirizine, desloratadine, fexofenadine, levocetirizine, acrivastine, ebastine and mizolastine are second generation antihistamines. Second generation, non-sedating antihistamines are recommended as first line treatment for chronic spontaneous urticaria. Fexofenadine in higher doses in chronic spontaneous urticaria. Consensus statement on the management of urticaria. Titrated doses of benzodiazepines are effective e.
Your doctor can guide you to the right antihistamine for you. Another advantage of the newer antihistamines is that they're available in time-release versions. You may have taken antihistamines in the past and found it hard to concentrate or stay awake. They are less sedating due to the fact they are less lipophilic and do not cross the blood-brain-barrier as easily. Updosing of antihistamines to improve control of chronic urticaria.
All patients were started with fexofenadine mg tablet once daily. Because some can cause serious side effects or interact with other medications you are taking, be sure to let your doctor know all the medications you take. They simply do the job with fewer side effects.
Indian J Dermatol Venereol Leprol. In patients with inadequate control of symptoms, increase in dosage of non-sedating antihistamines up to four fold has been recommended.
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